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KMID : 1101420180500040484
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Korean Journal of Clinical Laboratory Science
2018 Volume.50 No. 4 p.484 ~ p.491
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Relationships of the Vitamin D and Platelet Indices in Sjogren’s Syndrome
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Gunay Nahide Ekici
Bugday Irfan
Akalin Tayfun
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Abstract
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Primer Sjogren's Syndrome (pSS) is an autoimmune/inflammatory illness. The platelet indices (PIs) indicate the inflammatory response and activity/severity of many diseases. A vitamin D deficiency is accompanied by the increased tendency of autoimmune diseases. This study investigated whether the vitamin D levels are related to the altered platelet indices in pSS. A total of 261 individuals were included in this analytical cross-sectional study. The laboratory data of pSS patients were evaluated and the relationship between the PIs and vitamin D status was examined. According to these findings, in patients with pSS, the vitamin D levels were lower than the healthy control group (P＜0.05). The vitamin D levels were negatively associated with PDW (P=0.012), but positively correlated with PCT (P＜0.001). The cut-off point was obtained with receiver operating characteristics (ROC) curves for PDW: 12.53 (AUC 0.921, sensitivity 90%,specificity 85%), for PCT; 0.29 (AUC 0.660, sensitivity 68%, specificity 55%). In multivariate linear regression analysis, the most significant parameters for the effects of PDW are the following: vitamin D (β=?0.373; t=?2.626; sig.=0.013) and plateletcrit (β=?0.308; t=?2.13; sig.=0.040). A vitamin D deficiency may be accompanied by changes in PIs in pSS. A higher PDW and lower PCT supports the underlying inflammation, which may be vitamin D related useful parameters to consider in approaching to pSS.
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KEYWORD
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Plateletcrit, Platelet distribution width, Sjogren’s syndrome, Vitamin D
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